PhD student immune regulation

UMC Utrecht

UMC Utrecht

Regio Utrecht
Vaste aanstelling
Niet nader bepaald


Immunotherapy, namely checkpoint inhibitors, has changed the treatment landscape for solid tumors, especially melanoma and non–small cell lung cancer. However, despite recent successes, only a subset of patients shows clinical response to therapy. This project aims to understand the signaling pathways that allow inhibitory receptor to function, and how inflammation impacts on these signaling pathways. You will study inhibitory receptor signaling during homeostasis and during inflammation with the goal to understand why checkpoint inhibition fails in a fraction of the patients.


You will be working in the Laboratory of Translational Immunology (LTI) at the UMC Utrecht in the research group of Prof. Linde Meyaard. The research group is interested in understanding the inhibitory receptor signaling pathways and their role in different diseases, with a focus to potential clinical applications and important unanswered mechanistic questions. Our group studies inhibitory immune receptors in infection, inflammation and cancer, in models and patient material from a sub-cellular to organism level. The LTI provides a lively, internationally oriented, scientific environment with excellent facilities.


A strong background in cellular and molecular biology is required and experience with immunology is a clear advantage. We are looking for a flexible team player with good communication skills in English, who can work independently, but also as part of a multinational team.

The maximum salary for this position (90-100%) is € 2.992,00 gross per month based on full-time employment (work week 36 hours). This job is based on a temporary position for 4 years with 1 year probation.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses, career opportunities and personal budget. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

More information

If you have any questions about this vacancy, please contact Mrs.Linde Meyaard, Professor immune regulation via phone contactinformatie (telefoonnummer) 6 or email

Acquisition based on this jobopening is not appreciated.

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